Other notable works by Williams include theme music for four Olympic Games, the NBC Nightly News, the rededication of the Statue of Liberty, the DreamWorks Pictures production logo, and the television series Lost in Space. Williams has also composed numerous classical concerti, and he served as the principal conductor of the Boston Pops Orchestra from 1980 to 1993; he is now the orchestra's conductor laureate.

Williams has won five Academy Awards, four Golden Globe Awards, seven BAFTA Awards, and 21 Grammy Awards. With 45 Academy Award nominations, Williams is, together with composer Alfred Newman, the second most nominated person, after Walt Disney. Williams was inducted into the Hollywood Bowl Hall of Fame in 2000, and was a recipient of the Kennedy Center Honors in 2004.

John Williams was born on February 8, 1932, in Flushing (Queens), New York, the son of Esther and John Williams, Sr. His father was a jazz drummer who played with the Raymond Scott Quintet.

In 1948, Williams moved to Los Angeles with his family. Williams attended North Hollywood High School and graduated in 1950. He later attended the University of California at Los Angeles (UCLA), and studied privately with composer Mario Castelnuovo-Tedesco. In 1952, Williams was drafted into the U.S. Air Force, where he conducted and arranged music for the Air Force Band as part of his assignments.

After his Air Force service ended in 1955, Williams moved to New York City and entered the Juilliard School, where he studied piano with Rosina Lhévinne. During this time, Williams worked as a jazz pianist in New York's many clubs and eventually studios, most notably for composer Henry Mancini. His fellow session musicians included Rolly Bundock on bass, Jack Sperling on drums, and Bob Bain on guitar—the same lineup featured on the Mr. Lucky television series. Williams was known as "Little Johnny Love" Williams during the early 1960s, and he served as music arranger and bandleader for a series of popular music albums with the singer Frankie Laine.

Williams was married to actress Barbara Ruick from 1956 until her death on March 3, 1974. The Williamses had three children: Jennifer (born 1956), Mark (born 1958), and Joseph (born 1960). Williams' younger son is one of the various lead singers the band "Toto" has had over the decades. John Williams married his second wife, Samantha Winslow, on July 21, 1980.

John Williams is an honorary member of Kappa Kappa Psi, the national fraternity for college band members.

While skilled in a variety of twentieth-century compositional idioms, Williams's most familiar style may be described as a form of neoromanticism, inspired by the same large-scale orchestral music of the late 19th century—especially the compositions of Richard Wagner and its concept of leitmotif—that inspired his film music predecessors.

After his studies at Juilliard, Williams returned to Los Angeles, where he began working as an orchestrator at film studios. Among other composers, Williams worked with Franz Waxman, Bernard Herrmann, and Alfred Newman, and also with his fellow orchestrators Conrad Salinger and Bob Franklyn. Williams was also a studio pianist, performing on film scores by composers such as Jerry Goldsmith, Elmer Bernstein, and Henry Mancini. Williams recorded with Henry Mancini on the film scores of Peter Gunn (1959), Days of Wine and Roses (1962), and Charade (1963). (Williams actually played the well-recognized opening riff to Mancini's Peter Gunn theme). Williams (often credited as "Johnny Williams") also composed the theme music for various TV programs in the late 1950s: The pilot episode of Gilligan's Island, the Kraft Suspense Theatre, Lost in Space (1965–68), The Time Tunnel (1966–67), and Land of the Giants (the last three created by the prolific TV producer, Irwin Allen).

Williams's first major film composition was for the B movie Daddy-O in 1958, and his first screen credit came two years later in Because They're Young. He soon gained notice in Hollywood for his versatility in composing jazz, piano, and symphonic music. Williams received his first nomination for an Academy Award for his film score for Valley of the Dolls (1967), and then was nominated again for his score for Goodbye, Mr. Chips (1969). Williams broke through to win his first Academy Award for his adapted score for the film Fiddler on the Roof (1971). By the early 1970s, Williams had also gained prominence as a composer for now–film producer Irwin Allen's disaster films, composing the scores for The Poseidon Adventure (1972), Earthquake (1974), and The Towering Inferno (1974) (the last two films sharing musical cues).